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    • Absolution Overview

    Abmart offers academic researchers, clinicians and product developers revolutionary technologies and products for fast, successful and cost-efficient discovery, detection and functional manipulation of proteins and chemical molecules. Our long-term goal is to create an antibody democracy so that anyone with any molecule in mind can have desired monoclonal antibodies, successfully and affordably.

    Broadly, our customers can access our technology capabilities for custom projects (called Absolution) or directly purchase catalog products (see AbStore). Absolution consists of a series of custom services for

    Protein research

    developing functional antibodies for difficult membrane proteins such as ion channels (Cell 157, 1393 C404, 2014; SEAL™)
    developing monoclonal antibodies against any target protein in 30 days (UrgentMab™)
    developing highly specific, high affinity monoclonal antibodies against a specified short peptide sequence, a modified sequence, a sequence variant (mutations) (AbFocus™)

    Proteome research

    developing proteome-scale monoclonal antibody libraries for diverse proteomes including tumor surface proteome and plant flower proteome (Mabome™ )
    differential proteomics: for example, for discovering novel cell surface CART/ADC targets and novel plasma biomarkers for early diagnostics of tumors (AbProfile™)
    antibody proteomics: for developing monoclonal antibodies for a defined proteome (for example, an organelle proteome or tissue proteome) (AbTarget™)

    Chemical immunology

    developing sensitive assays for measuring metabolites and chemical drugs (SMAL™ )
    Absolution-Custom Service

    Under Absolution-Custom Service, we offer three custom antibody development for detecting total protein (SEAL™ and UrgentMab™) or a specific protein sequence site (AbFocus™).

    Protein Research

    SEAL™

    A short-gun library approach for deep coverage of accessible protein surface sequences with a library of diverse, high affinity monoclonal antibodies to deliver performing antibodies against difficult proteins

    Recommended for Difficult targets (membrane proteins, transcription factors, soluble factors) or end-uses (flow cytometry, CHIP, IHC, functional, ELISA) Previously failed antibody attempts
    Development time 4-5 months
    Development cost $400-500 (Per antigen) (2-5 mAbs delivered)
    $2000-5000 (Per target) (8-20 antigens/target)

    PETAL™

    No available catalog antibodies; newly sequenced species Medium to high abundance proteins Need to prioritize targets from genomics/proteomics studies Need to have antibodies fast

    Recommended for No available catalog antibodies; newly sequenced species Medium to high abundance proteins Need to prioritize targets from genomics/proteomics studies Need to have antibodies fast
    Development time ~ 30 days
    Development cost $300-500 (Per antigen) (2-5 mAbs delivered)
    $1000-3000 (Per target) (3-10 antigens/target)

     

    AbFocus™

    Creating a panel of affordable, high quality antibodies for probing a target protein's functional sites

    Recommended for A specific protein site with putative biological importance (modifications, mutations, spliced junctions, et al) No available catalog antibodies newly discovered sites Predicted sites
    Development time ~ 3-5 months
    Development cost $999 (Per antigen) (2-5 mAbs delivered)
    $3000-5000 (Per target) (covers up to 5 sites/target)

    Proteome Research

    Under Absolution-Custom Service, we offer three custom proteome services for proteome-scale antibody development (Mabome™), discovery (AbTarget™) and differential protein profiling (AbProfile™)

    Mabome™

    Mabome™ (monoclonal antibody ome): proteome-scale antibody development

    Recommended for mAb libraries for an organelle, for a tissue, for a sub-proteome (cell surface, plasma, et al)
    Development time 6-9 months
    Development cost as low as $10 (Per mAb)
    $10,000-100,000 (Per target) (1000-10,000 mAbs)

    AbTarget™

    Delivering high quality, validated monoclonal antibodies against a large number (but unspecified) of proteins in a cell, organ, tissue, organelle or any complex protein sample

    Recommended for Large-scale reagent antibody development For relatively uncharacterized proteomes
    Development time 2-3 months
    Development cost as low as $1499 per successful mAb
    Antibody quality Western Blot, IF, IP validated

    AbProfile™

    Experience the first-ever working technology for antibody proteomics. Enabling reproducible, cost- effective and productive proteome-scale differential profiling for protein targets and biomarkers

    Recommended for Differential profiling at a proteome scale to discover protein targets/biomarkers by massively parrallel mAb arrays
    Project time 2-3 months
    Development cost $999 per successful differential target identification and validation

    Chemical Immunology

    Under Absolution-Custom Service, we offer custom antibody service for small molecules

    SMAL™

    Mabome™ Combining advanced antigen design and sophiscated chemical synthesis for small molecules with Abmart mAb technologies to produce highest quality mAbs

    Recommended for generating a library of high affinity mAbs for small chemical molecules such as drugs, metabolites, pesticides and antibiotics
    Project time 4-5 months
    Development cost as low as $2000/molecule