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    AbFocus™ is based on numerous technology components of SEAL™ with the only difference of antibody selection. That is, only monoclo al antibodies with specificity against the target antigen sites are selected while all other cross-reactive antibodies toward homologous target sites are discarded.

    SEAL™(Surface Epitope Antibody Library) is a library approach for deep coverage of a protein target with a large library of monoclonal antibodies against a large library of protein surface antigens. SEAL™ consists of novel technologies for antigen design, potent immunogen preparation, efficient animal immunization, and large-scale antibody screening to produce high affinity, highly specific antibodies.

    SEAL™ has proven to be a successful approach for developing antibodies for difficult applications (flow cytometry, IHC, IP and functional) against difficult targets such as membrane proteins (GPCRs, ion channels), transcription factors and signaling molecules. Further, we have built an industrialized monoclonal antibody assembly line for making SEAL™ antibodies so that the unit cost for each antibody development is only at a small fraction of traditional approaches. Together, SEAL™ offers an unprecedented freedom and success for monoclonal antibody discovery.